Demitrious Kelly has an absolutely fascinating blog about operations in a modern web environment.
The whole thing is worth reading, but his comments on the use of Amazon EC2 is particularly compelling.
Reading his post on using MySQL on EC2 shows what an interesting service EC2 is: the work arounds needed to get around the fact that EC2 has no persistent-between-reboots storage are interesting, but in some ways contribute a lot to the scalability and high-availability of systems built on it (if your database servers needs rebuilding every time they reboot, then you need to be able to make those rebuilds repeatable and automatic - exactly the same as if you need to scale your system).
As I’ve noted previously, there are other options for high-availability datastorage services, though.
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